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  3. /Rifampicin (Rifampin)

Rifampicin (Rifampin)

Rifadin, Rimactane, Rifampin

Antimycobacterial • Rifamycin antibiotic

Premium
Hepatotoxic

Half-life

3-4 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Inhibits bacterial DNA-dependent RNA polymerase; one of the most potent CYP enzyme inducers known

Classification

Drug Class

Antimycobacterial

Subclass

Rifamycin antibiotic

Brand Names

RifadinRimactaneRifampin

Key Properties

Half-life

3-4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Rifampicin (Rifampin) Drug Profile | PharmaGraphX