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Gleevec
Antineoplastic • Tyrosine kinase inhibitor
Half-life
18 hours (40 hours for active metabolite)
Protein Binding
95%
Metabolized By
CYP3A4
External
Drugs.comInhibits BCR-ABL, c-KIT, and PDGFR tyrosine kinases
Drug Class
Antineoplastic
Subclass
Tyrosine kinase inhibitor
Half-life
18 hours (40 hours for active metabolite)
Time for plasma concentration to decrease by 50%
Protein Binding
95%
Fraction bound to plasma proteins
Therapeutic Index
Wide
Margin between therapeutic and toxic doses