Drug Database

Apixaban

Eliquis

Anticoagulant

12 hoursCYP3A4

Clopidogrel

Plavix

Antiplatelet

6 hoursCYP2C19

15-20 minutes (dose-dependent)CYP2C9

Aspirin

Bayer

Antiplatelet

Atorvastatin

Lipitor

Statin

14 hoursCYP3A4

Simvastatin

Zocor

Statin

2-3 hoursCYP3A4

Amlodipine

Norvasc

Calcium channel blocker

30-50 hoursCYP3A4

Lisinopril

Zestril

ACE Inhibitor

12 hours

2 hours (active metabolite 6-9 hours)CYP2C9

Losartan

Cozaar

ARB

Digoxin

Lanoxin

Cardiac glycoside

36-48 hours

Amiodarone

Cordarone

Antiarrhythmic

40-55 daysCYP3A4

Sertraline

Zoloft

Antidepressant

26 hoursCYP2B6

1-3 days (norfluoxetine 4-16 days)CYP2D6

Fluoxetine

Prozac

Antidepressant

5 hours (active metabolite 11 hours)CYP2D6

Venlafaxine

Effexor XR

Antidepressant

Tramadol

Ultram

Analgesic

6-7 hoursCYP2D6

Omeprazole

Prilosec

Proton pump inhibitor

0.5-1 hourCYP2C19

Ibuprofen

Advil

NSAID

2 hoursCYP2C9

Oxycodone

OxyContin

Opioid

3-5 hoursCYP3A4

Morphine

MS Contin

Opioid

2-4 hoursUGT2B7

Alprazolam

Xanax

Benzodiazepine

6-12 hoursCYP3A4

Diazepam

Valium

Benzodiazepine

20-100 hoursCYP2C19

Ketoconazole

Nizoral

Antifungal

2-8 hoursCYP3A4

Fluconazole

Diflucan

Antifungal

30 hoursCYP2C9

7-42 hours (dose-dependent)CYP2C9

Phenytoin

Dilantin

Antiepileptic

Quetiapine

Seroquel

Antipsychotic

6-7 hoursCYP3A4

Acetaminophen (Paracetamol)

Tylenol

Analgesic

1-4 hoursCYP2E1

Lithium

Lithobid

Mood stabilizer

18-36 hours

Sildenafil

Viagra

PDE5 inhibitor

3-5 hoursCYP3A4

Rifampicin (Rifampin)

Rifadin

Antimycobacterial

3-4 hoursCYP3A4

1-4 hours (varies with acetylator status)NAT2 (N-acetyltransferase)

Isoniazid

Nydrazid

Antimycobacterial

Amoxicillin

Amoxil

Antibiotic

1-1.5 hours

Ampicillin

Principen

Antibiotic

1-2 hours

Piperacillin-Tazobactam

Zosyn

Antibiotic

0.7-1.2 hours

Ceftriaxone

Rocephin

Antibiotic

6-9 hours

Cefazolin

Ancef

Antibiotic

1.8 hours

Cephalexin

Keflex

Antibiotic

0.5-1.2 hours

Cefepime

Maxipime

Antibiotic

2 hours

Ciprofloxacin

Cipro

Antibiotic

4 hoursCYP1A2

Levofloxacin

Levaquin

Antibiotic

6-8 hours

Moxifloxacin

Avelox

Antibiotic

12 hoursUGT1A1

Azithromycin

Zithromax

Antibiotic

68 hours

Clarithromycin

Biaxin

Antibiotic

3-7 hoursCYP3A4

Erythromycin

Ery-Tab

Antibiotic

1.5-2 hoursCYP3A4

Metformin

Glucophage

Antidiabetic

4-8.7 hours

Glipizide

Glucotrol

Antidiabetic

2-4 hoursCYP2C9

Glyburide

DiaBeta

Antidiabetic

4-10 hoursCYP2C9

Sitagliptin

Januvia

Antidiabetic

12.4 hoursCYP3A4

Empagliflozin

Jardiance

Antidiabetic

12.4 hoursUGT1A3

Liraglutide

Victoza

Antidiabetic

13 hours

Insulin Glargine

Lantus

Antidiabetic

24 hours (duration)

Metoprolol

Lopressor

Beta blocker

3-7 hoursCYP2D6

Carvedilol

Coreg

Beta blocker

7-10 hoursCYP2D6

Atenolol

Tenormin

Beta blocker

6-7 hours

Propranolol

Inderal

Beta blocker

3-6 hoursCYP2D6

Hydrochlorothiazide

Microzide

Diuretic

6-15 hours

Furosemide

Lasix

Diuretic

2 hours

1.4 hours (active metabolites longer)CYP3A4

Spironolactone

Aldactone

Diuretic

Haloperidol

Haldol

Antipsychotic

14-26 hoursCYP3A4

3-20 hours (varies by CYP2D6 status)CYP2D6

Risperidone

Risperdal

Antipsychotic

Olanzapine

Zyprexa

Antipsychotic

21-54 hoursCYP1A2

Aripiprazole

Abilify

Antipsychotic

75-94 hoursCYP3A4

Clozapine

Clozaril

Antipsychotic

8-12 hoursCYP1A2

Levetiracetam

Keppra

Antiepileptic

6-8 hours

Lamotrigine

Lamictal

Antiepileptic

25-33 hoursUGT1A4

Valproic Acid

Depakene

Antiepileptic

9-16 hoursCYP2C9

25-65 hours initially, then 12-17 hours (auto-induction)CYP3A4

Carbamazepine

Tegretol

Antiepileptic

Acyclovir

Zovirax

Antiviral

2.5-3.3 hours

Valacyclovir

Valtrex

Antiviral

2.5-3.3 hours

6-10 hours (active metabolite)Hepatic esterases

Oseltamivir

Tamiflu

Antiviral

Tacrolimus

Prograf

Immunosuppressant

11-16 hoursCYP3A4

Cyclosporine

Sandimmune

Immunosuppressant

8-27 hoursCYP3A4

Mycophenolate Mofetil

CellCept

Immunosuppressant

17.9 hours (MPA)UGT

Pantoprazole

Protonix

Proton pump inhibitor

1 hourCYP2C19

Esomeprazole

Nexium

Proton pump inhibitor

1-1.5 hoursCYP2C19

Ondansetron

Zofran

Antiemetic

3-6 hoursCYP3A4

Metoclopramide

Reglan

Antiemetic

5-6 hoursCYP2D6

7.8 hours (inhaled)CYP3A4

Albuterol

Proventil

Bronchodilator

3-6 hours

Fluticasone

Flovent

Corticosteroid

Montelukast

Singulair

Anti-asthma

2.7-5.5 hoursCYP2C8

Tiotropium

Spiriva

Bronchodilator

25 hoursCYP2D6

Cyclobenzaprine

Flexeril

Muscle relaxant

18 hoursCYP1A2

Baclofen

Lioresal

Muscle relaxant

3-4 hours

Tizanidine

Zanaflex

Muscle relaxant

2.5 hoursCYP1A2

Levothyroxine

Synthroid

Thyroid hormone

6-7 days

Methimazole

Tapazole

Antithyroid

5-6 hours

2-3 hours (biological half-life 18-36 hours)CYP3A4

Prednisone

Deltasone

Corticosteroid

Dexamethasone

Decadron

Corticosteroid

36-54 hoursCYP3A4

Tamoxifen

Nolvadex

Antineoplastic

5-7 daysCYP2D6

3-10 hours (dose-dependent)

Methotrexate

Trexall

Antineoplastic

1-2 hours (active metabolite 18-30 hours)

Allopurinol

Zyloprim

Antigout

Colchicine

Colcrys

Antigout

27-31 hoursCYP3A4

Alendronate

Fosamax

Bisphosphonate

>10 years (in bone)

2-4 hours (IR); 3.5 hours (ER)CES1A1

Methylphenidate

Ritalin

CNS Stimulant

Amphetamine Mixed Salts

Adderall

CNS Stimulant

9-14 hoursCYP2D6

Atomoxetine

Strattera

ADHD Treatment

5 hours (extensive metabolizers); 21 hours (poor metabolizers)CYP2D6

<1 hour (prodrug); 9-11 hours (d-amphetamine)Red blood cell hydrolysis

Lisdexamfetamine

Vyvanse

CNS Stimulant

Buspirone

Buspar

Anxiolytic

2-3 hoursCYP3A4

Hydroxyzine

Vistaril

Antihistamine

20 hoursCYP3A4

Isotretinoin

Accutane

Retinoid

21 hoursCYP2C8

5-6 hours (elderly: 8 hours)CYP3A4

Finasteride

Propecia

Androgen inhibitor

Tamsulosin

Flomax

Alpha blocker

9-13 hoursCYP3A4

Oxybutynin

Ditropan

Urinary antispasmodic

2-3 hours (IR); 12-13 hours (ER)CYP3A4

Solifenacin

Vesicare

Urinary antispasmodic

45-68 hoursCYP3A4

17 minutes (active metabolite)

Latanoprost

Xalatan

Antiglaucoma

Timolol (Ophthalmic)

Timoptic

Antiglaucoma

4 hoursCYP2D6

Ethinyl Estradiol/Levonorgestrel

Alesse

Contraceptive

EE: 12-23 hours; LNG: 24-32 hoursCYP3A4

Ivermectin

Stromectol

Antiparasitic

18 hoursCYP3A4

Mebendazole

Vermox

Antiparasitic

2.5-5.5 hoursCYP1A2

3-4.5 hours (IR); 6-9 hours (ER)CYP3A4

Diltiazem

Cardizem

Calcium channel blocker

6-8 hours (single dose); 12 hours (chronic)CYP3A4

Verapamil

Calan

Calcium channel blocker

3-7 hoursNAT2 (acetylation)

Hydralazine

Apresoline

Vasodilator

5 hoursHepatic denitration

Isosorbide Mononitrate

Imdur

Nitrate

Nitroglycerin

Nitrostat

Nitrate

1-4 minutesHepatic first-pass

Ranolazine

Ranexa

Antianginal

7 hoursCYP3A4

Naproxen

Aleve

NSAID

12-17 hoursCYP2C9

Meloxicam

Mobic

NSAID

15-20 hoursCYP2C9

Celecoxib

Celebrex

NSAID

11 hoursCYP2C9

Ketorolac

Toradol

NSAID

5-6 hoursCYP2C9

Indomethacin

Indocin

NSAID

4.5 hoursCYP2C9

Mirtazapine

Remeron

Antidepressant

20-40 hoursCYP1A2

Bupropion

Wellbutrin

Antidepressant

21 hoursCYP2B6

Vortioxetine

Trintellix

Antidepressant

66 hoursCYP2D6

Nortriptyline

Pamelor

Antidepressant

18-44 hoursCYP2D6

Doxepin

Sinequan

Antidepressant

8-24 hoursCYP2C19

Cetirizine

Zyrtec

Antihistamine

8.3 hoursCYP3A4

8.4 hours (active metabolite 28 hours)CYP3A4

Loratadine

Claritin

Antihistamine

Fexofenadine

Allegra

Antihistamine

14.4 hours

Diphenhydramine

Benadryl

Antihistamine

2.4-9.3 hoursCYP2D6

Zolpidem

Ambien

Hypnotic

2.5-3 hoursCYP3A4

Eszopiclone

Lunesta

Hypnotic

6 hoursCYP3A4

Suvorexant

Belsomra

Hypnotic

12 hoursCYP3A4

Ramelteon

Rozerem

Hypnotic

1-2.6 hoursCYP1A2

Hydroxychloroquine

Plaquenil

DMARD

40-50 daysCYP2D6

5-10 hoursIntestinal bacteria

Sulfasalazine

Azulfidine

DMARD

15-18 days (active metabolite)CYP1A2

Leflunomide

Arava

DMARD

Azathioprine

Imuran

Immunosuppressant

5 hoursTPMT

14 daysProteolytic degradation

Adalimumab

Humira

Biologic

102 hoursProteolytic degradation

Etanercept

Enbrel

Biologic

Infliximab

Remicade

Biologic

7.7-9.5 daysProteolytic degradation

22 days (after first dose); 76 days (after fourth dose)Proteolytic degradation

Rituximab

Rituxan

Biologic

28.5 daysProteolytic degradation

Trastuzumab

Herceptin

Biologic

Imatinib

Gleevec

Antineoplastic

18 hours (40 hours for active metabolite)CYP3A4

Erlotinib

Tarceva

Antineoplastic

36 hoursCYP3A4

40-60 hours (80-110 hours for active metabolite)CYP3A4

Sunitinib

Sutent

Antineoplastic

0.75 hours (5-FU terminal: 0.5-1 hour)Carboxylesterase

Letrozole

Femara

Antineoplastic

48 hoursCYP3A4

Anastrozole

Arimidex

Antineoplastic

50 hoursCYP3A4

Capecitabine

Xeloda

Antineoplastic

Sumatriptan

Imitrex

Antimigraine

2-2.5 hoursMAO-A

Rizatriptan

Maxalt

Antimigraine

2-3 hoursMAO-A

Topiramate

Topamax

Antiepileptic

21 hoursCYP3A4

8-12 hoursMinimal metabolism

Levodopa-Carbidopa

Sinemet

Antiparkinson

1.5 hoursDDC

Pramipexole

Mirapex

Antiparkinson

Ropinirole

Requip

Antiparkinson

6 hoursCYP1A2

10 hours (metabolites 18-25 hours)CYP2B6

Selegiline

Eldepryl

Antiparkinson

Donepezil

Aricept

Anti-dementia

70 hoursCYP2D6

Memantine

Namenda

Anti-dementia

60-80 hours

1.5 hours (effects persist 10 hours)Cholinesterase-mediated hydrolysis

Rivastigmine

Exelon

Anti-dementia

Gabapentin

Neurontin

Anticonvulsant

5-7 hours

Pregabalin

Lyrica

Anticonvulsant

6.3 hours

4 hours (active metabolite 12 hours)Dihydrodiol dehydrogenase

Modafinil

Provigil

Wake-promoting agent

15 hoursCYP3A4

Naltrexone

Revia

Opioid antagonist

Disulfiram

Antabuse

Alcohol deterrent

60-120 hoursCYP1A2

24 hoursMinimal metabolism

Varenicline

Chantix

Smoking cessation

Doxycycline

Vibramycin

Antibiotic

18-22 hours

Minocycline

Minocin

Antibiotic

11-22 hoursCYP3A4

Tetracycline

Sumycin

Antibiotic

6-12 hours

Gentamicin

Garamycin

Antibiotic

2-3 hours

Amikacin

Amikin

Antibiotic

2-3 hours

Tobramycin

Nebcin

Antibiotic

2-3 hours

Vancomycin

Vancocin

Antibiotic

4-6 hours

Linezolid

Zyvox

Antibiotic

4.5-5.5 hoursMAO-A

Metronidazole

Flagyl

Antibiotic

8 hoursCYP3A4

Clindamycin

Cleocin

Antibiotic

2.4 hoursCYP3A4

TMP: 8-10 hours; SMX: 10-13 hoursCYP2C9

Trimethoprim-Sulfamethoxazole

Bactrim

Antibiotic

Nitrofurantoin

Macrobid

Antibiotic

20-60 minutes

21 hours (64 hours with chronic dosing)CYP3A4

Itraconazole

Sporanox

Antifungal

6 hours (dose-dependent)CYP2C19

Voriconazole

Vfend

Antifungal

Amphotericin B

Fungizone

Antifungal

15 days

Nystatin

Mycostatin

Antifungal

36 hours (effective tissue half-life: 200-400 hours)CYP2C9

Terbinafine

Lamisil

Antifungal

Polyethylene Glycol 3350

Miralax

Laxative

Lactulose

Enulose

Laxative

Bisacodyl

Dulcolax

Laxative

16 hours

Potassium Chloride

K-Dur

Electrolyte

Magnesium Oxide

Mag-Ox 400

Electrolyte

Calcium Carbonate

Tums

Electrolyte