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  3. /Warfarin

Warfarin

Coumadin, Jantoven

Anticoagulant • Vitamin K antagonist

Premium
NTIBleeding

Half-life

40 h

Protein Binding

Metabolized By

CYP2C9, CYP3A4, CYP1A2

External

Drugs.com

Mechanism of Action

Inhibits vitamin K-dependent clotting factors (II, VII, IX, X)

Indications(5)

Atrial fibrillation — stroke preventionDeep vein thrombosisPulmonary embolismMechanical heart valvesVenous thromboembolism prophylaxis

Classification

Drug Class

Anticoagulant

Subclass

Vitamin K antagonist

Brand Names

CoumadinJantoven

Key Properties

Half-life

40 h

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Warfarin Drug Profile | PharmaGraphX