Metronidazole

Flagyl, MetroGel, Metrocream, Rosadan, Nuvessa, MetroLotion, Noritate, Likmez, Vandazole, Nydamax, Pylera

Antibiotic • Nitroimidazole

Premium

CNS DepressantHepatotoxic

Half-life

8 hours

Protein Binding

<20%

Metabolized By

CYP3A4

External

Drugs.com

Boxed warning

Carcinogenic in rodents (use only when necessary)

Clinical alerts

Boxed warning

1 boxed warning

Hepatotoxic

Monitor liver function

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Activated in anaerobic organisms to form toxic metabolites that damage DNA

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Myocardial Infarction (MI)
·Tobacco Use
·Smoking Cessation
·Aortic Stenosis
·Elective Endovascular Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours

Interactions

1 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
warfarin	major	Increased INR and bleeding risk

Common adverse effects

Nausea
Metallic taste
Headache
Dizziness
Peripheral neuropathy (prolonged use)

Food, alcohol & herbal

Food

Take with food to reduce GI upset

Alcohol · major

Disulfiram-like reaction — AVOID alcohol during and 3 days after

Pharmacokinetics

Half-life: 8 hours
Protein binding: <20%
Metabolised by: CYP3A4
Inhibits: CYP2C9

Pregnancy & lactation

Not recorded for Metronidazole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Metronidazole

Flagyl, MetroGel, Metrocream, Rosadan, Nuvessa, MetroLotion, Noritate, Likmez, Vandazole, Nydamax, Pylera

Antibiotic • Nitroimidazole

Premium

CNS DepressantHepatotoxic

Half-life

8 hours

Protein Binding

<20%

Metabolized By

CYP3A4

External

Drugs.com

Boxed warning

Carcinogenic in rodents (use only when necessary)

Clinical alerts

Boxed warning

1 boxed warning

Hepatotoxic

Monitor liver function

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Activated in anaerobic organisms to form toxic metabolites that damage DNA

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Myocardial Infarction (MI)
·Tobacco Use
·Smoking Cessation
·Aortic Stenosis
·Elective Endovascular Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours

Interactions

1 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
warfarin	major	Increased INR and bleeding risk

Common adverse effects

Nausea
Metallic taste
Headache
Dizziness
Peripheral neuropathy (prolonged use)

Food, alcohol & herbal

Food

Take with food to reduce GI upset

Alcohol · major

Disulfiram-like reaction — AVOID alcohol during and 3 days after

Pharmacokinetics

Half-life: 8 hours
Protein binding: <20%
Metabolised by: CYP3A4
Inhibits: CYP2C9

Pregnancy & lactation

Not recorded for Metronidazole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Metronidazole Drug Profile | PharmaGraphX