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  3. /Metronidazole

Metronidazole

Flagyl, MetroGel, Metrocream, Rosadan, Nuvessa, MetroLotion, Noritate, Likmez, Vandazole, Nydamax, Pylera

Antibiotic • Nitroimidazole

Premium
CNS DepressantHepatotoxic

Half-life

8 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Activated in anaerobic organisms to form toxic metabolites that damage DNA

Indications(5)

Myocardial Infarction (MI)Tobacco UseSmoking CessationAortic StenosisElective Endovascular Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours

Classification

Drug Class

Antibiotic

Subclass

Nitroimidazole

Brand Names

FlagylMetroGelMetrocreamRosadanNuvessaMetroLotionNoritateLikmezVandazoleNydamaxPylera

Key Properties

Half-life

8 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Metronidazole Drug Profile | PharmaGraphX