Aspirin

Bayer, Ecotrin

Antiplatelet • COX inhibitor / NSAID

BleedingNephrotoxic

Half-life

15-20 minutes (dose-dependent)

Protein Binding

80-90%

Metabolized By

CYP2C9

External

Irreversibly inhibits COX-1, preventing thromboxane A2 synthesis

Drug Class

Antiplatelet

Subclass

COX inhibitor / NSAID

BayerEcotrin

Half-life

15-20 minutes (dose-dependent)

Time for plasma concentration to decrease by 50%

Protein Binding

80-90%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses