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  3. /Ibuprofen

Ibuprofen

Advil, Motrin, Duexis, Proprinal, Ibudone, Xylon, Genpril, Ibu, Vicoprofen, Combogesic, Samson 8, Reprexain, Neoprofen, Wal-Profen, Ibuprohm, Caldolor, Motrin PM, Addaprin

NSAID • Propionic acid derivative

Premium
BleedingNephrotoxic

Half-life

2 hours

Protein Binding

Metabolized By

CYP2C9, CYP2C19

External

Drugs.com

Mechanism of Action

Non-selective COX-1 and COX-2 inhibitor, reducing prostaglandin synthesis

Indications(5)

RehabilitationShock WaveImpingement SyndromeOpioid TaperingPain, Postoperative

Classification

Drug Class

NSAID

Subclass

Propionic acid derivative

Brand Names

AdvilMotrinDuexisProprinalIbudoneXylonGenprilIbuVicoprofenCombogesicSamson 8ReprexainNeoprofenWal-ProfenIbuprohmCaldolorMotrin PMAddaprin

Key Properties

Half-life

2 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ibuprofen Drug Profile | PharmaGraphX