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Advil, Motrin, Duexis, Proprinal, Ibudone, Xylon, Genpril, Ibu, Vicoprofen, Combogesic, Samson 8, Reprexain, Neoprofen, Wal-Profen, Ibuprohm, Caldolor, Motrin PM, Addaprin
NSAID • Propionic acid derivative
PremiumNon-selective COX-1 and COX-2 inhibitor, reducing prostaglandin synthesis
From the drug index — may include conditions studied rather than approved indications
3 curated · 3 major or contraindicated · select a row for management
| Interacting drug | Severity | Effect |
|---|---|---|
| lithium | major | Lithium toxicity — neurotoxicity, cardiac arrhythmias, renal damage. |
| methotrexate | major | Methotrexate toxicity — myelosuppression, hepatotoxicity, mucositis. |
| warfarin | major | Dramatically increased bleeding risk. NSAIDs also cause GI erosion, compounding the hemorrhagic risk. |
Significant increase in GI bleeding risk. Avoid concurrent use.
Not recorded for Ibuprofen. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Assembled from: drug index, curated drug database, curated interaction pairs.
