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  3. /Fluconazole

Fluconazole

Diflucan

Antifungal • Azole antifungal

Premium
QT RiskHepatotoxic

Half-life

53.2 h

Protein Binding

Metabolized By

CYP2C9, CYP3A4

External

Drugs.com

Mechanism of Action

Inhibits fungal CYP450-dependent lanosterol demethylase

Indications(5)

Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple MyelomaMyelodysplastic SyndromesBacterial Vaginosis

Classification

Drug Class

Antifungal

Subclass

Azole antifungal

Brand Names

Diflucan

Key Properties

Half-life

53.2 h

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Fluconazole Drug Profile | PharmaGraphX