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  3. /Tacrolimus

Tacrolimus

Prograf, Astagraf XL, Envarsus XR, Astagraf, Envarsus, Protopic

Immunosuppressant • Calcineurin inhibitor

Premium
NTIQT RiskNephrotoxic

Half-life

11-16 hours

Protein Binding

Metabolized By

CYP3A4, CYP3A5

External

Drugs.com

Mechanism of Action

Binds to FKBP-12, inhibiting calcineurin and preventing T-cell activation

Indications(5)

AMLMDSAcute LeukemiaAcute Myeloid LeukemiaMyelodysplastic Syndromes

Classification

Drug Class

Immunosuppressant

Subclass

Calcineurin inhibitor

Brand Names

PrografAstagraf XLEnvarsus XRAstagrafEnvarsusProtopic

Key Properties

Half-life

11-16 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Tacrolimus Drug Profile | PharmaGraphX