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  3. /Sildenafil

Sildenafil

Viagra, Revatio, Liqrev, Vybrique

PDE5 inhibitor • Phosphodiesterase-5 inhibitor

Premium

Half-life

3-5 hours

Protein Binding

Metabolized By

CYP3A4, CYP2C9

External

Drugs.com

Mechanism of Action

Inhibits PDE5, increasing cGMP and causing smooth muscle relaxation

Indications(5)

DysmenorrheaMenstrual PainHypoxic-Ischemic EncephalopathyBronchopulmonary DysplasiaErectile Dysfunction

Classification

Drug Class

PDE5 inhibitor

Subclass

Phosphodiesterase-5 inhibitor

Brand Names

ViagraRevatioLiqrevVybrique

Key Properties

Half-life

3-5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Sildenafil Drug Profile | PharmaGraphX