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  3. /Apixaban

Apixaban

Eliquis

Anticoagulant • Direct factor Xa inhibitor

Premium
Bleeding

Half-life

12 h

Protein Binding

Metabolized By

CYP3A4, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP2C19

External

Drugs.com

Mechanism of Action

Directly inhibits factor Xa, reducing thrombin generation

Indications(5)

CirrhosisSplenectomyPortal Vein ThrombosisHypertension, PortalVenous Thromboembolism

Classification

Drug Class

Anticoagulant

Subclass

Direct factor Xa inhibitor

Brand Names

Eliquis

Key Properties

Half-life

12 h

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Apixaban Drug Profile | PharmaGraphX