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  3. /Ketoconazole

Ketoconazole

Nizoral, T8 Keto Flush, Ketodan, Mal-A-Ket, Ketochlor, Keto-C, Malacetic, Mal-A-Ket Wipes, Recorlev, Kuric, Xolegel, Extina

Antifungal • Azole antifungal

Premium
QT RiskHepatotoxic

Half-life

2-8 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Inhibits ergosterol synthesis; POTENT CYP3A4 inhibitor

Indications(5)

Anatomic Stage IV Breast Cancer AJCC v8AstrocytomaBreast Carcinoma Metastatic in the BrainGliomaInvasive Breast Carcinoma

Classification

Drug Class

Antifungal

Subclass

Azole antifungal

Brand Names

NizoralT8 Keto FlushKetodanMal-A-KetKetochlorKeto-CMalaceticMal-A-Ket WipesRecorlevKuricXolegelExtina

Key Properties

Half-life

2-8 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ketoconazole Drug Profile | PharmaGraphX