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  3. /Atorvastatin

Atorvastatin

Lipitor, Atorvaliq, Caduet

Statin • HMG-CoA reductase inhibitor

Premium
Hepatotoxic

Half-life

14 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Competitively inhibits HMG-CoA reductase, reducing cholesterol synthesis

Indications(5)

Acute Coronary Syndromes (ACS)OverweightObesityDyslipidaemiaAlagille Syndrome

Classification

Drug Class

Statin

Subclass

HMG-CoA reductase inhibitor

Brand Names

LipitorAtorvaliqCaduet

Key Properties

Half-life

14 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Atorvastatin Drug Profile | PharmaGraphX