Atorvastatin

Lipitor

Statin • HMG-CoA reductase inhibitor

Hepatotoxic

Half-life

14 hours

Protein Binding

>=98%

Metabolized By

CYP3A4

External

Competitively inhibits HMG-CoA reductase, reducing cholesterol synthesis

Drug Class

Statin

Subclass

HMG-CoA reductase inhibitor

Lipitor

Half-life

14 hours

Time for plasma concentration to decrease by 50%

Protein Binding

>=98%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses