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Sandimmune, Neoral, Gengraf
Immunosuppressant • Calcineurin inhibitor
Binds to cyclophilin, inhibiting calcineurin and preventing T-cell activation
Drug Class
Immunosuppressant
Subclass
Calcineurin inhibitor
Half-life
8-27 hours
Time for plasma concentration to decrease by 50%
Protein Binding
90%
Fraction bound to plasma proteins
Therapeutic Index
Narrow
Margin between therapeutic and toxic doses