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Zocor, Flolipid, Vytorin
Statin • HMG-CoA reductase inhibitor
PremiumProdrug converted to active form that inhibits HMG-CoA reductase
7 curated · 7 major or contraindicated · select a row for management
| Interacting drug | Severity | Effect |
|---|---|---|
| clarithromycin | contraindicated | Up to 10-fold increase in simvastatin levels, high risk of myopathy and rhabdomyolysis |
| itraconazole | contraindicated | Major increase in statin levels with high rhabdomyolysis risk |
| ketoconazole | contraindicated | Severe rhabdomyolysis risk — muscle breakdown causing renal failure. |
| amiodarone | major | Increased myopathy/rhabdomyolysis risk |
| daptomycin | major | Increased risk of rhabdomyolysis |
| diltiazem | major | 5-fold increase in simvastatin exposure, elevated myopathy risk |
| rifampicin | major | Near-complete loss of statin efficacy; LDL cholesterol control lost. |
Additive hepatotoxicity risk
Not recorded for Simvastatin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Assembled from: drug index, curated drug database, curated interaction pairs.
