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  3. /Diltiazem

Diltiazem

Cardizem, Cardizem CD, Tiazac, Dilacor, Matzim, Tiadylt, Taztia, Cartia, Dilt, Diltzac

Calcium channel blocker • Non-dihydropyridine CCB

Premium
QT Risk

Half-life

3-4.5 hours (IR); 6-9 hours (ER)

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Blocks L-type calcium channels in cardiac and smooth muscle

Indications(5)

HealthyMalignant Digestive System NeoplasmSupraventricular Tachycardia (SVT)Atrioventricular Nodal Re Entrant TachycardiaPremature Ventricular Complexes

Classification

Drug Class

Calcium channel blocker

Subclass

Non-dihydropyridine CCB

Brand Names

CardizemCardizem CDTiazacDilacorMatzimTiadyltTaztiaCartiaDiltDiltzac

Key Properties

Half-life

3-4.5 hours (IR); 6-9 hours (ER)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Diltiazem Drug Profile | PharmaGraphX