Diltiazem

Cardizem, Cardizem CD, Tiazac, Dilacor

Calcium channel blocker • Non-dihydropyridine CCB

QT Risk

Half-life

3-4.5 hours (IR); 6-9 hours (ER)

Protein Binding

70-80%

Metabolized By

CYP3A4

External

Blocks L-type calcium channels in cardiac and smooth muscle

Drug Class

Calcium channel blocker

Subclass

Non-dihydropyridine CCB

CardizemCardizem CDTiazacDilacor

Half-life

3-4.5 hours (IR); 6-9 hours (ER)

Time for plasma concentration to decrease by 50%

Protein Binding

70-80%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses