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  3. /Isoniazid

Isoniazid

Nydrazid, Laniazid, INH

Antimycobacterial • Isonicotinic acid hydrazide

Premium
Hepatotoxic

Half-life

1-4 hours (varies with acetylator status)

Protein Binding

Metabolized By

NAT2 (N-acetyltransferase)

External

Drugs.com

Mechanism of Action

Inhibits mycolic acid synthesis in mycobacterial cell walls; potent CYP2E1 inhibitor

Indications(5)

TuberculosisTuberculosis, PulmonaryTuberculosis, Lymph NodeMycobacterium TuberculosisTuberculosis, Latent

Classification

Drug Class

Antimycobacterial

Subclass

Isonicotinic acid hydrazide

Brand Names

NydrazidLaniazidINH

Key Properties

Half-life

1-4 hours (varies with acetylator status)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Isoniazid Drug Profile | PharmaGraphX