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  3. /Phenytoin

Phenytoin

Dilantin, Euthasol, Euthaphen, Phenytek

Antiepileptic • Hydantoin

Premium
NTICNS DepressantHepatotoxic

Half-life

7-42 hours (dose-dependent)

Protein Binding

Metabolized By

CYP2C9, CYP2C19

External

Drugs.com

Mechanism of Action

Blocks voltage-gated sodium channels; zero-order kinetics at therapeutic levels

Indications(4)

Generalised tonic-clonic seizuresFocal (partial) seizuresStatus epilepticus (IV formulation)Seizure prophylaxis after neurosurgery

Classification

Drug Class

Antiepileptic

Subclass

Hydantoin

Brand Names

DilantinEuthasolEuthaphenPhenytek

Key Properties

Half-life

7-42 hours (dose-dependent)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Phenytoin Drug Profile | PharmaGraphX