Metformin

Glucophage, Glucophage XR, Fortamet

Antidiabetic • Biguanide

Half-life

4-8.7 hours

Protein Binding

Negligible

Metabolized By

N/A

External

Decreases hepatic gluconeogenesis and increases insulin sensitivity

Drug Class

Antidiabetic

Subclass

Biguanide

GlucophageGlucophage XRFortamet

Half-life

4-8.7 hours

Time for plasma concentration to decrease by 50%

Protein Binding

Negligible

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses