Skip to main content
PharmaGraphX
PharmaGraphX
Log inGet Started

Important Disclaimer

PharmaGraphX is a research and educational tool only. It is NOT intended for clinical decision-making, patient care, or medical advice. All drug information, calculations, interactions, and recommendations are for educational and research purposes only. Always consult qualified healthcare professionals, official drug labeling (FDA, TGA, EMA), and institutional guidelines before making any clinical decisions. The developers assume no liability for any decisions made based on information provided by this platform.

© 2026 PharmaGraphX. All rights reserved.

|

For research and educational purposes only. Not medical advice.

Help
  • Navigate between workspaces using the left sidebar.
  • Use the main chat to ask any pharmacology question.
  • Press G then H to quickly navigate home.
Navigation
HomeG H
PK/PD StudioG P
Interaction HubG A
Digital TwinG T
Molecular LabG M

Press Esc to close

  1. Home
  2. /Database
  3. /Carbamazepine

Carbamazepine

Tegretol, Tegretol XR, Carbatrol, Epitol, Equetro

Antiepileptic • Sodium channel blocker

Premium
NTICNS DepressantHepatotoxic

Half-life

25-65 hours initially, then 12-17 hours (auto-induction)

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Stabilizes neuronal membranes by blocking voltage-sensitive sodium channels

Indications(4)

Epilepsy — focal and generalised tonic-clonic seizuresTrigeminal neuralgiaBipolar disorder — manic episodesGlossopharyngeal neuralgia

Classification

Drug Class

Antiepileptic

Subclass

Sodium channel blocker

Brand Names

TegretolTegretol XRCarbatrolEpitolEquetro

Key Properties

Half-life

25-65 hours initially, then 12-17 hours (auto-induction)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Carbamazepine Drug Profile | PharmaGraphX