Acetaminophen (Paracetamol)

Tylenol, Paracetamol, Panadol, Calpol

Analgesic • Non-opioid analgesic / Antipyretic

Hepatotoxic

Half-life

1-4 hours

Protein Binding

10-25%

Metabolized By

CYP2E1, CYP1A2, CYP3A4

External

Inhibits central COX; exact mechanism not fully understood; acts centrally

Drug Class

Analgesic

Subclass

Non-opioid analgesic / Antipyretic

TylenolParacetamolPanadolCalpol

Half-life

1-4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

10-25%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses