Tramadol Drug Profile | PharmaGraphX

Boxed warning

Boxed warning

3 boxed warnings

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

CNS depressant

Additive sedation with other CNS depressants and alcohol

Weak mu-opioid agonist + serotonin/norepinephrine reuptake inhibitor

4 curated · 4 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
bupropion	major	Increased seizure risk; reduced pain control
fluoxetine	major	Serotonin syndrome and reduced pain control with paradoxically increased seizure risk.
mirtazapine	major	Risk of serotonin syndrome; mirtazapine lowers seizure threshold
sertraline	major	Serotonin syndrome: potentially life-threatening. Also increased seizure risk.

Alcohol · major

Severe respiratory depression and CNS depression risk. CONTRAINDICATED.

Herbal

Not recorded for Tramadol. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Assembled from: drug index, curated drug database, curated interaction pairs.