Sertraline

Zoloft

Antidepressant • SSRI

Premium

BleedingSerotoninergic

Half-life

26 hours

Protein Binding

98%

Metabolized By

CYP2B6, CYP2C19, CYP3A4, CYP2D6

External

Drugs.com

Boxed warning

Suicidality risk in children, adolescents, and young adults

Clinical alerts

Boxed warning

1 boxed warning

Bleeding risk

Additive with other antithrombotics and NSAIDs

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Selectively inhibits serotonin reuptake in the synapse

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Depression - Major Depressive Disorder
·Depressive Episodes
·Major Depressive Disorder (MDD)
·Breast Cancer Survivor
·Depression

Interactions

3 curated · 3 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
linezolid	contraindicated	Life-threatening serotonin syndrome
methamphetamine	major	Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability)
tramadol	major	Serotonin syndrome: potentially life-threatening. Also increased seizure risk.

Common adverse effects

Nausea
Diarrhea
Insomnia
Sexual dysfunction
Headache

Food, alcohol & herbal

Alcohol · major

Increased CNS depression and impairment. Avoid alcohol.

Herbal

St. John's Wort (major) — Serotonin syndrome risk — CONTRAINDICATED
SAMe (major) — Serotonin syndrome risk
Tryptophan (major) — Serotonin syndrome risk

Pharmacokinetics

Half-life: 26 hours
Protein binding: 98%
Metabolised by: CYP2B6, CYP2C19, CYP3A4, CYP2D6
Inhibits: CYP2D6

Pregnancy & lactation

Not recorded for Sertraline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Sertraline

Zoloft

Antidepressant • SSRI

Premium

BleedingSerotoninergic

Half-life

26 hours

Protein Binding

98%

Metabolized By

CYP2B6, CYP2C19, CYP3A4, CYP2D6

External

Drugs.com

Boxed warning

Suicidality risk in children, adolescents, and young adults

Clinical alerts

Boxed warning

1 boxed warning

Bleeding risk

Additive with other antithrombotics and NSAIDs

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Selectively inhibits serotonin reuptake in the synapse

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Depression - Major Depressive Disorder
·Depressive Episodes
·Major Depressive Disorder (MDD)
·Breast Cancer Survivor
·Depression

Interactions

3 curated · 3 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
linezolid	contraindicated	Life-threatening serotonin syndrome
methamphetamine	major	Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability)
tramadol	major	Serotonin syndrome: potentially life-threatening. Also increased seizure risk.

Common adverse effects

Nausea
Diarrhea
Insomnia
Sexual dysfunction
Headache

Food, alcohol & herbal

Alcohol · major

Increased CNS depression and impairment. Avoid alcohol.

Herbal

St. John's Wort (major) — Serotonin syndrome risk — CONTRAINDICATED
SAMe (major) — Serotonin syndrome risk
Tryptophan (major) — Serotonin syndrome risk

Pharmacokinetics

Half-life: 26 hours
Protein binding: 98%
Metabolised by: CYP2B6, CYP2C19, CYP3A4, CYP2D6
Inhibits: CYP2D6

Pregnancy & lactation

Not recorded for Sertraline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Sertraline Drug Profile | PharmaGraphX