Linezolid

Zyvox

Antibiotic • Oxazolidinone

Premium

Serotoninergic

Half-life

4.5-5.5 hours

Protein Binding

31%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Myelosuppression (monitor CBC weekly)
Serotonin syndrome with serotonergic drugs

Clinical alerts

Boxed warning

2 boxed warnings

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Binds to 23S rRNA of 50S ribosomal subunit, inhibiting initiation of translation

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
·Mycobacterium Abscessus Pulmonary Disease
·Mycobacterium Abscessus Infection
·Non-Tuberculous Mycobacterial (NTM) Infections
·Non-Tuberculous Mycobacteria Pulmonary Disease

Monitoring

Therapeutic range: 2–8 mg/L; AUC/MIC > 80-120

Interactions

2 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
sertraline	contraindicated	Life-threatening serotonin syndrome
ethanol	moderate	Hypertensive crisis possible with tyramine-containing foods/drinks

Common adverse effects

Diarrhea
Headache
Nausea
Myelosuppression
Peripheral neuropathy

Food, alcohol & herbal

Food

Avoid tyramine-rich foods — MAO-A inhibition can cause hypertensive crisis

Alcohol · moderate

May worsen side effects

Herbal

St. John's Wort (major) — Serotonin syndrome risk

Pharmacokinetics

Published parameters · PMID:15328152

Half-life: 4.5-5.5 hours
Protein binding: 31%
Inhibits: MAO-A
Clearance: 6 L/h; adult patients with Gram-positive infections
Volume of distribution: 40 L
Bioavailability: 100%
Renally eliminated: 30%
Model: 1-compartment

Pregnancy & lactation

Not recorded for Linezolid. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs, published PK literature.

Not a substitute for clinical judgement

Linezolid

Zyvox

Antibiotic • Oxazolidinone

Premium

Serotoninergic

Half-life

4.5-5.5 hours

Protein Binding

31%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Myelosuppression (monitor CBC weekly)
Serotonin syndrome with serotonergic drugs

Clinical alerts

Boxed warning

2 boxed warnings

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Binds to 23S rRNA of 50S ribosomal subunit, inhibiting initiation of translation

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
·Mycobacterium Abscessus Pulmonary Disease
·Mycobacterium Abscessus Infection
·Non-Tuberculous Mycobacterial (NTM) Infections
·Non-Tuberculous Mycobacteria Pulmonary Disease

Monitoring

Therapeutic range: 2–8 mg/L; AUC/MIC > 80-120

Interactions

2 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
sertraline	contraindicated	Life-threatening serotonin syndrome
ethanol	moderate	Hypertensive crisis possible with tyramine-containing foods/drinks

Common adverse effects

Diarrhea
Headache
Nausea
Myelosuppression
Peripheral neuropathy

Food, alcohol & herbal

Food

Avoid tyramine-rich foods — MAO-A inhibition can cause hypertensive crisis

Alcohol · moderate

May worsen side effects

Herbal

St. John's Wort (major) — Serotonin syndrome risk

Pharmacokinetics

Published parameters · PMID:15328152

Half-life: 4.5-5.5 hours
Protein binding: 31%
Inhibits: MAO-A
Clearance: 6 L/h; adult patients with Gram-positive infections
Volume of distribution: 40 L
Bioavailability: 100%
Renally eliminated: 30%
Model: 1-compartment

Pregnancy & lactation

Not recorded for Linezolid. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs, published PK literature.

Not a substitute for clinical judgement

Linezolid Drug Profile | PharmaGraphX