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  3. /Mirtazapine

Mirtazapine

Remeron, Remeron SolTab, Mirataz

Antidepressant • Noradrenergic and specific serotonergic antidepressant (NaSSA)

Premium
SerotoninergicCNS Depressant

Half-life

20-40 hours

Protein Binding

Metabolized By

CYP1A2, CYP2D6, CYP3A4

External

Drugs.com

Mechanism of Action

Blocks presynaptic alpha-2 receptors and 5-HT2/5-HT3 receptors; also H1 antagonist

Indications(5)

RETT Syndrome With Proven MECP2 MutationAdvanced CancerAnorexiaWeight LossInsomnia

Classification

Drug Class

Antidepressant

Subclass

Noradrenergic and specific serotonergic antidepressant (NaSSA)

Brand Names

RemeronRemeron SolTabMirataz

Key Properties

Half-life

20-40 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Mirtazapine Drug Profile | PharmaGraphX