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  3. /Bupropion

Bupropion

Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Forfivo, Contrave, Auvelity, Aplenzin

Antidepressant • NDRI (Norepinephrine-dopamine reuptake inhibitor)

Premium

Half-life

21 hours

Protein Binding

Metabolized By

CYP2B6

External

Drugs.com

Mechanism of Action

Inhibits reuptake of norepinephrine and dopamine; no serotonergic activity

Indications(5)

HealthyObesityHealthy Study ParticipantsHealthy VolunteersLoss-of-control Eating

Classification

Drug Class

Antidepressant

Subclass

NDRI (Norepinephrine-dopamine reuptake inhibitor)

Brand Names

WellbutrinWellbutrin SRWellbutrin XLZybanForfivoContraveAuvelityAplenzin

Key Properties

Half-life

21 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Bupropion Drug Profile | PharmaGraphX