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  3. /Acyclovir

Acyclovir

Zovirax, Sitavig, Avaclyr, Xerese

Antiviral • Nucleoside analog

Premium
Nephrotoxic

Half-life

2.5-3.3 hours

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Selectively phosphorylated by viral thymidine kinase, then inhibits viral DNA polymerase

Classification

Drug Class

Antiviral

Subclass

Nucleoside analog

Brand Names

ZoviraxSitavigAvaclyrXerese

Key Properties

Half-life

2.5-3.3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Acyclovir Drug Profile | PharmaGraphX