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Zonisamide

Zonisade, Zonegran

Biologic agent

Standard

Half-life

63 hours

Protein Binding

40%

Metabolized By

N/A

External

Drugs.com

Clinical alerts

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Blocks sodium and T-type calcium channels; also has weak carbonic anhydrase inhibition

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Seizures
·Seizures, Focal
·Seizure, Partial Onset
·Seizure Disorder, Partial
·Seizure, Partial

Interactions

No curated interaction pairs are recorded for Zonisamide. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Somnolence
Anorexia
Dizziness
Kidney stones

Food, alcohol & herbal

Alcohol · moderate

Additive CNS depression

Pharmacokinetics

Half-life: 63 hours
Protein binding: 40%
Metabolised by: CYP3A4

Pregnancy & lactation

Not recorded for Zonisamide. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement