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  3. /Zolpidem

Zolpidem

Ambien, Ambien CR, Edluar, Intermezzo, Zolpimist

Hypnotic • Non-benzodiazepine (Z-drug)

Premium
CNS Depressant

Half-life

2.5-3 hours

Protein Binding

Metabolized By

CYP3A4, CYP1A2, CYP2C9

External

Drugs.com

Mechanism of Action

Binds selectively to GABA-A receptor alpha-1 subunit

Indications(5)

AutismAutism Spectrum DisorderNon-visual Effects of LightChronic Variable Sleep DeficiencySleep Disordered Breathing

Classification

Drug Class

Hypnotic

Subclass

Non-benzodiazepine (Z-drug)

Brand Names

AmbienAmbien CREdluarIntermezzoZolpimist

Key Properties

Half-life

2.5-3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Zolpidem Drug Profile | PharmaGraphX