Zolpidem

Ambien, Ambien CR, Edluar, Intermezzo

Hypnotic • Non-benzodiazepine (Z-drug)

CNS Depressant

Half-life

2.5-3 hours

Protein Binding

92%

Metabolized By

CYP3A4, CYP1A2, CYP2C9

External

Binds selectively to GABA-A receptor alpha-1 subunit

Drug Class

Hypnotic

Subclass

Non-benzodiazepine (Z-drug)

AmbienAmbien CREdluarIntermezzo

Half-life

2.5-3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

92%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses