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Ziprasidone

Geodon

Uncategorized

Standard

Half-life

6-7 hours

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased mortality in elderly with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Antagonist at D2, 5-HT2A, 5-HT1D receptors; agonist at 5-HT1A; inhibits NE and 5-HT reuptake

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Treatment-resistant Schizophrenia
·Schizophrenia
·Schizoaffective Disorder
·Bipolar Disorder
·Antipsychotics

Interactions

No curated interaction pairs are recorded for Ziprasidone. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Somnolence
Dizziness
Nausea
Akathisia

Food, alcohol & herbal

Food

Take with food — increases absorption 2-fold

Alcohol · major

Additive CNS depression

Pharmacokinetics

Half-life: 6-7 hours
Protein binding: 99%
Metabolised by: CYP3A4

Pregnancy & lactation

Not recorded for Ziprasidone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Ziprasidone

Geodon

Uncategorized

Standard

Half-life

6-7 hours

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased mortality in elderly with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Antagonist at D2, 5-HT2A, 5-HT1D receptors; agonist at 5-HT1A; inhibits NE and 5-HT reuptake

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Treatment-resistant Schizophrenia
·Schizophrenia
·Schizoaffective Disorder
·Bipolar Disorder
·Antipsychotics

Interactions

No curated interaction pairs are recorded for Ziprasidone. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Somnolence
Dizziness
Nausea
Akathisia

Food, alcohol & herbal

Food

Take with food — increases absorption 2-fold

Alcohol · major

Additive CNS depression

Pharmacokinetics

Half-life: 6-7 hours
Protein binding: 99%
Metabolised by: CYP3A4

Pregnancy & lactation

Not recorded for Ziprasidone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement