Vortioxetine

Trintellix

Antidepressant • Multimodal serotonin modulator

BleedingSerotoninergic

Half-life

66 hours

Protein Binding

98%

Metabolized By

CYP2D6, CYP3A4

External

SERT inhibitor + 5-HT1A agonist + 5-HT1B partial agonist + 5-HT3/5-HT7 antagonist

Drug Class

Antidepressant

Subclass

Multimodal serotonin modulator

Trintellix

Half-life

66 hours

Time for plasma concentration to decrease by 50%

Protein Binding

98%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses