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Venlafaxine

Effexor XR, Effexor

Antidepressant • SNRI

Premium

BleedingSerotoninergic

Half-life

5 hours (active metabolite 11 hours)

Protein Binding

27%

Metabolized By

CYP2D6, CYP3A4

External

Drugs.com

Boxed warning

Suicidality risk in children, adolescents, and young adults

Clinical alerts

Boxed warning

1 boxed warning

Bleeding risk

Additive with other antithrombotics and NSAIDs

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Inhibits serotonin and norepinephrine reuptake; weak dopamine reuptake inhibition

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Rheumatoid Arthritis
·Herpes Zoster
·Pain
·Postherpetic Neuralgia
·Hot Flashes

Interactions

No curated interaction pairs are recorded for Venlafaxine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Headache
Insomnia
Hypertension
Sexual dysfunction

Food, alcohol & herbal

Alcohol · major

Increased CNS depression and impairment

Herbal

St. John's Wort (major) — Serotonin syndrome risk

Pharmacokinetics

Half-life: 5 hours (active metabolite 11 hours)
Protein binding: 27%
Metabolised by: CYP2D6, CYP3A4

Pregnancy & lactation

Not recorded for Venlafaxine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Venlafaxine

Effexor XR, Effexor

Antidepressant • SNRI

Premium

BleedingSerotoninergic

Half-life

5 hours (active metabolite 11 hours)

Protein Binding

27%

Metabolized By

CYP2D6, CYP3A4

External

Drugs.com

Boxed warning

Suicidality risk in children, adolescents, and young adults

Clinical alerts

Boxed warning

1 boxed warning

Bleeding risk

Additive with other antithrombotics and NSAIDs

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Inhibits serotonin and norepinephrine reuptake; weak dopamine reuptake inhibition

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Rheumatoid Arthritis
·Herpes Zoster
·Pain
·Postherpetic Neuralgia
·Hot Flashes

Interactions

No curated interaction pairs are recorded for Venlafaxine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Headache
Insomnia
Hypertension
Sexual dysfunction

Food, alcohol & herbal

Alcohol · major

Increased CNS depression and impairment

Herbal

St. John's Wort (major) — Serotonin syndrome risk

Pharmacokinetics

Half-life: 5 hours (active metabolite 11 hours)
Protein binding: 27%
Metabolised by: CYP2D6, CYP3A4

Pregnancy & lactation

Not recorded for Venlafaxine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement