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  3. /Venlafaxine

Venlafaxine

Effexor XR, Effexor

Antidepressant • SNRI

Premium
BleedingSerotoninergic

Half-life

5 hours (active metabolite 11 hours)

Protein Binding

Metabolized By

CYP2D6, CYP3A4

External

Drugs.com

Mechanism of Action

Inhibits serotonin and norepinephrine reuptake; weak dopamine reuptake inhibition

Indications(5)

Rheumatoid ArthritisHerpes ZosterPainPostherpetic NeuralgiaHot Flashes

Classification

Drug Class

Antidepressant

Subclass

SNRI

Brand Names

Effexor XREffexor

Key Properties

Half-life

5 hours (active metabolite 11 hours)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Venlafaxine Drug Profile | PharmaGraphX