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Varenicline

Chantix, Tyrvaya

Smoking cessation • Nicotinic receptor partial agonist

Premium

Half-life

24 hours

Protein Binding

<20%

Metabolized By

Minimal metabolism

External

Drugs.com

Boxed warning

Neuropsychiatric events (behavior changes, hostility, suicidal ideation) — boxed warning removed in 2016 but monitor closely

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Partial agonist at alpha-4/beta-2 nicotinic receptors; reduces craving and withdrawal

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Tobacco Use Disorder
·Tobacco Use Cessation
·Cannabis Use
·Cannabis Use Disorder
·Marijuana Use

Interactions

No curated interaction pairs are recorded for Varenicline. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Insomnia
Abnormal dreams
Headache
Constipation

Food, alcohol & herbal

Food

Take after eating with full glass of water to reduce nausea

Alcohol · moderate

May increase alcohol intoxication effects; some reports of unusual behavior

Pharmacokinetics

Half-life: 24 hours
Protein binding: <20%
Metabolised by: Minimal metabolism

Pregnancy & lactation

Not recorded for Varenicline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Varenicline

Chantix, Tyrvaya

Smoking cessation • Nicotinic receptor partial agonist

Premium

Half-life

24 hours

Protein Binding

<20%

Metabolized By

Minimal metabolism

External

Drugs.com

Boxed warning

Neuropsychiatric events (behavior changes, hostility, suicidal ideation) — boxed warning removed in 2016 but monitor closely

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Partial agonist at alpha-4/beta-2 nicotinic receptors; reduces craving and withdrawal

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Tobacco Use Disorder
·Tobacco Use Cessation
·Cannabis Use
·Cannabis Use Disorder
·Marijuana Use

Interactions

No curated interaction pairs are recorded for Varenicline. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Insomnia
Abnormal dreams
Headache
Constipation

Food, alcohol & herbal

Food

Take after eating with full glass of water to reduce nausea

Alcohol · moderate

May increase alcohol intoxication effects; some reports of unusual behavior

Pharmacokinetics

Half-life: 24 hours
Protein binding: <20%
Metabolised by: Minimal metabolism

Pregnancy & lactation

Not recorded for Varenicline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement