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  3. /Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Bactrim, Septra, Bactrim DS

Antibiotic • Folate antagonist combination

Premium
QT RiskHepatotoxicNephrotoxic

Half-life

TMP: 8-10 hours; SMX: 10-13 hours

Protein Binding

Metabolized By

CYP2C9, CYP3A4

External

Drugs.com

Mechanism of Action

Sequential blockade of folate synthesis (sulfamethoxazole + trimethoprim)

Classification

Drug Class

Antibiotic

Subclass

Folate antagonist combination

Brand Names

BactrimSeptraBactrim DS

Key Properties

Half-life

TMP: 8-10 hours; SMX: 10-13 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Trimethoprim-Sulfamethoxazole Drug Profile | PharmaGraphX