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Bactrim, Septra, Bactrim DS
Antibiotic • Folate antagonist combination
Half-life
TMP: 8-10 hours; SMX: 10-13 hours
Protein Binding
TMP: 45%; SMX: 70%
Metabolized By
CYP2C9, CYP3A4
External
Drugs.comSequential blockade of folate synthesis (sulfamethoxazole + trimethoprim)
Drug Class
Antibiotic
Subclass
Folate antagonist combination
Half-life
TMP: 8-10 hours; SMX: 10-13 hours
Time for plasma concentration to decrease by 50%
Protein Binding
TMP: 45%; SMX: 70%
Fraction bound to plasma proteins
Therapeutic Index
Wide
Margin between therapeutic and toxic doses