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Bactrim, Septra, Bactrim DS
Antibiotic • Folate antagonist combination
PremiumHalf-life
TMP: 8-10 hours; SMX: 10-13 hours
Protein Binding
TMP: 45%; SMX: 70%
Metabolized By
CYP2C9, CYP3A4
External
Drugs.comSequential blockade of folate synthesis (sulfamethoxazole + trimethoprim)
1 curated · 1 major or contraindicated · select a row for management
| Interacting drug | Severity | Effect |
|---|---|---|
| methotrexate | contraindicated | Severe methotrexate toxicity (pancytopenia, mucositis, nephrotoxicity) |
May increase side effects
Not recorded for Trimethoprim-Sulfamethoxazole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Assembled from: drug index, curated drug database, curated interaction pairs.
