Tranylcypromine Drug Profile

Boxed warning

Suicidality in children, adolescents, and young adults
Hypertensive crisis with tyramine-rich foods

Clinical alerts

Boxed warning

2 boxed warnings

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

Hepatotoxic

Monitor liver function

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

Irreversibly inhibits monoamine oxidase A and B, increasing NE, 5-HT, and DA

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Middle Ear Disease
·Hemorrhage
·Bariatric Surgery
·Obesity, Morbid
·Postpartum Hemorrhage

Interactions

No curated interaction pairs are recorded for Tranylcypromine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Orthostatic hypotension
Insomnia
Dry mouth
Dizziness

Food, alcohol & herbal

Food

Strict tyramine-free diet required — hypertensive crisis risk with aged cheeses, fermented foods, cured meats

Alcohol · major

Hypertensive crisis risk if tyramine present in alcohol

Herbal

St. John's Wort (major) — Fatal serotonin syndrome risk

Pharmacokinetics

Half-life: 2.5 hours
Protein binding: N/A

Pregnancy & lactation

Not recorded for Tranylcypromine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.