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  3. /Topiramate

Topiramate

Topamax, Trokendi XR, Qudexy XR, Qsymia, Trokendi, Qudexy, Eprontia

Antiepileptic • Sulfamate-substituted monosaccharide

Premium
CNS DepressantNephrotoxic

Half-life

21 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Multiple: blocks Na+ channels, enhances GABA, inhibits glutamate, weak carbonic anhydrase inhibitor

Classification

Drug Class

Antiepileptic

Subclass

Sulfamate-substituted monosaccharide

Brand Names

TopamaxTrokendi XRQudexy XRQsymiaTrokendiQudexyEprontia

Key Properties

Half-life

21 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Topiramate Drug Profile | PharmaGraphX