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  3. /Tobramycin

Tobramycin

Nebcin, Tobi, Bethkis, Kitabis, Tobradex, Tobrex, Zylet

Antibiotic • Aminoglycoside

Premium
NTINephrotoxic

Half-life

2-3 hours

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Binds to 30S ribosomal subunit, inhibiting protein synthesis

Indications(5)

Prosthetic-joint InfectionKnee InfectionArthroplasty ComplicationsJoint InfectionArthroplasty, Replacement, Knee

Classification

Drug Class

Antibiotic

Subclass

Aminoglycoside

Brand Names

NebcinTobiBethkisKitabisTobradexTobrexZylet

Key Properties

Half-life

2-3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Tobramycin Drug Profile | PharmaGraphX