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Tigecycline

Tygacil

Tetracycline antibiotic

Standard

Half-life

42 hours

Protein Binding

71-89%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased all-cause mortality vs comparators — reserve for situations where alternatives not suitable

Clinical alerts

Boxed warning

1 boxed warning

Hepatotoxic

Monitor liver function

Mechanism of action

Binds 30S ribosomal subunit; overcomes ribosomal protection and efflux resistance mechanisms

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Blood-Brain Barrier
·Bacterial Meningitis
·Mycobacterium Abscessus Pulmonary Disease
·Mycobacterium Abscessus Infection
·Non-Tuberculous Mycobacterial (NTM) Infections

Interactions

No curated interaction pairs are recorded for Tigecycline. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Vomiting
Diarrhea
Abdominal pain

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Half-life: 42 hours
Protein binding: 71-89%

Pregnancy & lactation

Not recorded for Tigecycline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Tigecycline

Tygacil

Tetracycline antibiotic

Standard

Half-life

42 hours

Protein Binding

71-89%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased all-cause mortality vs comparators — reserve for situations where alternatives not suitable

Clinical alerts

Boxed warning

1 boxed warning

Hepatotoxic

Monitor liver function

Mechanism of action

Binds 30S ribosomal subunit; overcomes ribosomal protection and efflux resistance mechanisms

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Blood-Brain Barrier
·Bacterial Meningitis
·Mycobacterium Abscessus Pulmonary Disease
·Mycobacterium Abscessus Infection
·Non-Tuberculous Mycobacterial (NTM) Infections

Interactions

No curated interaction pairs are recorded for Tigecycline. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Vomiting
Diarrhea
Abdominal pain

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Half-life: 42 hours
Protein binding: 71-89%

Pregnancy & lactation

Not recorded for Tigecycline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement