Theophylline Drug Profile

Mechanism of action

Phosphodiesterase 4 inhibitor

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Acute Exacerbation of Chronic Obstructive Pulmonary Disease
·Influenza, Human
·Virus Diseases
·Pseudohypoparathyroidism
·Pseudohypoparathyroidism Type 1a

Dosing

Typical adult starting point — always confirm against local guidelines

Typical dose: [object Object] mg every 12 h; Oral

Monitoring

Therapeutic range: 5–15 mg/L; Trough
Steady state: ~2-3 days
Re-check: After initiation/dose change; then every 6-12 months

Trough: before next dose
Peak: 1-2h post-dose (IR), 4-6h (SR)

Interactions

No curated interaction pairs are recorded for Theophylline. This is not a statement that none exist — check a full interaction reference before combining.

Pharmacokinetics

Published parameters · PMID:3282851

Clearance: 2.8 L/h; adult patients
Volume of distribution: 30 L
Bioavailability: 96%
Renally eliminated: 10%
Model: 1-compartment

Pregnancy & lactation

Not recorded for Theophylline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, published PK literature, TDM population profiles.

Theophylline is not in the curated set, so interactions, adverse effects and safety flags are unavailable for it — the page shows identity and classification only.