Sulfasalazine

Azulfidine, Azulfidine EN-tabs

DMARD • Aminosalicylate / Sulfonamide

HepatotoxicNephrotoxic

Half-life

5-10 hours

Protein Binding

99%

Metabolized By

Intestinal bacteria, NAT2

External

Cleaved by gut bacteria to 5-ASA and sulfapyridine; anti-inflammatory and immunomodulatory

Drug Class

DMARD

Subclass

Aminosalicylate / Sulfonamide

AzulfidineAzulfidine EN-tabs

Half-life

5-10 hours

Time for plasma concentration to decrease by 50%

Protein Binding

99%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses