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Aldactone
Diuretic • Potassium-sparing diuretic / Aldosterone antagonist
Half-life
1.4 hours (active metabolites longer)
Protein Binding
>90%
Metabolized By
CYP3A4, CYP2C8
External
Drugs.comCompetitive antagonist of aldosterone at the mineralocorticoid receptor
Drug Class
Diuretic
Subclass
Potassium-sparing diuretic / Aldosterone antagonist
Half-life
1.4 hours (active metabolites longer)
Time for plasma concentration to decrease by 50%
Protein Binding
>90%
Fraction bound to plasma proteins
Therapeutic Index
Wide
Margin between therapeutic and toxic doses