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Risperidone

Risperdal, Risperdal Consta, Perseris, Uzedy, Rykindo

Antipsychotic • Second-generation (atypical) antipsychotic

Premium

QT RiskCNS Depressant

Half-life

3-20 hours (varies by CYP2D6 status)

Protein Binding

90%

Metabolized By

CYP2D6

External

Drugs.com

Boxed warning

Increased mortality in elderly patients with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Antagonizes dopamine D2 and serotonin 5-HT2A receptors

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Major Depression Moderate
·Major Depression Severe
·Major Depression
·Depression - Major Depressive Disorder
·Anhedonia

Interactions

No curated interaction pairs are recorded for Risperidone. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Weight gain
Hyperprolactinemia
EPS
Sedation
Metabolic syndrome

Food, alcohol & herbal

Alcohol · major

Additive CNS depression

Pharmacokinetics

Half-life: 3-20 hours (varies by CYP2D6 status)
Protein binding: 90%
Metabolised by: CYP2D6

Pregnancy & lactation

Not recorded for Risperidone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Risperidone

Risperdal, Risperdal Consta, Perseris, Uzedy, Rykindo

Antipsychotic • Second-generation (atypical) antipsychotic

Premium

QT RiskCNS Depressant

Half-life

3-20 hours (varies by CYP2D6 status)

Protein Binding

90%

Metabolized By

CYP2D6

External

Drugs.com

Boxed warning

Increased mortality in elderly patients with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Antagonizes dopamine D2 and serotonin 5-HT2A receptors

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Major Depression Moderate
·Major Depression Severe
·Major Depression
·Depression - Major Depressive Disorder
·Anhedonia

Interactions

No curated interaction pairs are recorded for Risperidone. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Weight gain
Hyperprolactinemia
EPS
Sedation
Metabolic syndrome

Food, alcohol & herbal

Alcohol · major

Additive CNS depression

Pharmacokinetics

Half-life: 3-20 hours (varies by CYP2D6 status)
Protein binding: 90%
Metabolised by: CYP2D6

Pregnancy & lactation

Not recorded for Risperidone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement