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  3. /Ranolazine

Ranolazine

Ranexa, Aspruzyo

Antianginal • Late sodium current inhibitor

Premium
QT Risk

Half-life

7 hours

Protein Binding

Metabolized By

CYP3A4, CYP2D6

External

Drugs.com

Mechanism of Action

Inhibits late sodium current, reducing intracellular calcium and myocardial oxygen demand

Indications(5)

STEMI (ST Elevation MI)Amyotrophic Lateral SclerosisPulmonary HypertensionRight Ventricular DysfunctionRight Heart Failure

Classification

Drug Class

Antianginal

Subclass

Late sodium current inhibitor

Brand Names

RanexaAspruzyo

Key Properties

Half-life

7 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ranolazine Drug Profile | PharmaGraphX