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Ramipril

Altace, Vostally

ACE inhibitor

Standard

Half-life

13-17 hours (ramiprilat)

Protein Binding

73%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Fetal toxicity — discontinue when pregnancy detected

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Prodrug converted to ramiprilat; inhibits ACE, reducing angiotensin II

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Heart Failure NYHA Class II
·Glioblastoma
·Radiotherapy; Complications
·Cognitive Decline
·Chemoradiation

Interactions

No curated interaction pairs are recorded for Ramipril. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Cough
Dizziness
Hyperkalemia

Food, alcohol & herbal

Food

Potassium-rich foods and potassium-containing salt substitutes may worsen hyperkalemia

Alcohol · moderate

Additive hypotension

Pharmacokinetics

Half-life: 13-17 hours (ramiprilat)
Protein binding: 73%
Metabolised by: CYP3A4

Pregnancy & lactation

Pregnancy category: D

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Ramipril

Altace, Vostally

ACE inhibitor

Standard

Half-life

13-17 hours (ramiprilat)

Protein Binding

73%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Fetal toxicity — discontinue when pregnancy detected

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Prodrug converted to ramiprilat; inhibits ACE, reducing angiotensin II

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Heart Failure NYHA Class II
·Glioblastoma
·Radiotherapy; Complications
·Cognitive Decline
·Chemoradiation

Interactions

No curated interaction pairs are recorded for Ramipril. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Cough
Dizziness
Hyperkalemia

Food, alcohol & herbal

Food

Potassium-rich foods and potassium-containing salt substitutes may worsen hyperkalemia

Alcohol · moderate

Additive hypotension

Pharmacokinetics

Half-life: 13-17 hours (ramiprilat)
Protein binding: 73%
Metabolised by: CYP3A4

Pregnancy & lactation

Pregnancy category: D

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement