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  3. /Ramelteon

Ramelteon

Rozerem

Hypnotic • Melatonin receptor agonist

Premium
CNS DepressantHepatotoxic

Half-life

1-2.6 hours

Protein Binding

Metabolized By

CYP1A2, CYP2C9, CYP3A4

External

Drugs.com

Mechanism of Action

Agonist at MT1 and MT2 melatonin receptors in suprachiasmatic nucleus

Indications(5)

Circadian Rhythm DisordersChronic Insomnia CharacterizedChronic InsomniaDeliriumREM Behavior Disorder

Classification

Drug Class

Hypnotic

Subclass

Melatonin receptor agonist

Brand Names

Rozerem

Key Properties

Half-life

1-2.6 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ramelteon Drug Profile | PharmaGraphX