Propranolol

Blocks both beta-1 and beta-2 adrenergic receptors

• ·Autism Spectrum Disorder
• ·Challenging Behaviour
• ·Aggression
• ·Severe Disruptive Behaviour Disorders
• ·Self-injury

Therapeutic range

0.02–0.2 mg/L

No curated interaction pairs are recorded for Propranolol. This is not a statement that none exist — check a full interaction reference before combining.

• Fatigue
• Bradycardia
• Cold extremities
• Bronchospasm
• Depression

Half-life

3-6 hours

Protein binding

90%

Metabolised by

CYP2D6, CYP1A2, CYP2C19

Clearance

60 L/h

adult patients

Volume of distribution

270 L

Bioavailability

35%

Renally eliminated

1%

Model

1-compartment

Not recorded for Propranolol. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.