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  3. /Pregabalin

Pregabalin

Lyrica, Lyrica CR, Bonqat

Anticonvulsant • GABA analog / Calcium channel modulator

Premium
CNS Depressant

Half-life

6.3 hours

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Binds to alpha-2-delta subunit of voltage-gated calcium channels (more potent than gabapentin)

Indications(5)

Painful Diabetic Neuropathy (PDN)Peripheral Neuropathy With Type 2 DiabetesVegan DietOpioid TaperingCoronary Artery Bypass

Classification

Drug Class

Anticonvulsant

Subclass

GABA analog / Calcium channel modulator

Brand Names

LyricaLyrica CRBonqat

Key Properties

Half-life

6.3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Pregabalin Drug Profile | PharmaGraphX