Pregabalin

Lyrica, Lyrica CR

Anticonvulsant • GABA analog / Calcium channel modulator

CNS Depressant

Half-life

6.3 hours

Protein Binding

Metabolized By

N/A

External

Binds to alpha-2-delta subunit of voltage-gated calcium channels (more potent than gabapentin)

Drug Class

Anticonvulsant

Subclass

GABA analog / Calcium channel modulator

LyricaLyrica CR

Half-life

6.3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses