Pramipexole

Mirapex, Mirapex ER

Antiparkinson • Dopamine agonist (D2/D3 preferring)

CNS Depressant

Half-life

8-12 hours

Protein Binding

15%

Metabolized By

Minimal metabolism

External

Directly stimulates D2 and D3 dopamine receptors in the striatum

Drug Class

Antiparkinson

Subclass

Dopamine agonist (D2/D3 preferring)

MirapexMirapex ER

Half-life

8-12 hours

Time for plasma concentration to decrease by 50%

Protein Binding

15%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses