Skip to main content
PharmaGraphX
PharmaGraphX
Log inGet Started

Important Disclaimer

PharmaGraphX is a research and educational tool only. It is NOT intended for clinical decision-making, patient care, or medical advice. All drug information, calculations, interactions, and recommendations are for educational and research purposes only. Always consult qualified healthcare professionals, official drug labeling (FDA, TGA, EMA), and institutional guidelines before making any clinical decisions. The developers assume no liability for any decisions made based on information provided by this platform.

© 2026 PharmaGraphX. All rights reserved.

|

For research and educational purposes only. Not medical advice.

Help
  • Navigate between workspaces using the left sidebar.
  • Use the main chat to ask any pharmacology question.
  • Press G then H to quickly navigate home.
Navigation
HomeG H
PK/PD StudioG P
Interaction HubG A
Digital TwinG T
Molecular LabG M

Press Esc to close

  1. Home
  2. /Database
  3. /Pramipexole

Pramipexole

Mirapex, Mirapex ER

Antiparkinson • Dopamine agonist (D2/D3 preferring)

Premium
CNS Depressant

Half-life

8-12 hours

Protein Binding

Metabolized By

Minimal metabolism

External

Drugs.com

Mechanism of Action

Directly stimulates D2 and D3 dopamine receptors in the striatum

Indications(5)

Major Depressive DisorderMild Neurocognitive DisorderHIVAdrenoleukodystrophyRestless Legs Syndrome

Classification

Drug Class

Antiparkinson

Subclass

Dopamine agonist (D2/D3 preferring)

Brand Names

MirapexMirapex ER

Key Properties

Half-life

8-12 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Pramipexole Drug Profile | PharmaGraphX