Piperacillin-Tazobactam

Zosyn

Antibiotic • Ureidopenicillin + Beta-lactamase inhibitor

BleedingNephrotoxic

Half-life

0.7-1.2 hours

Protein Binding

30%

Metabolized By

N/A

External

Piperacillin inhibits cell wall synthesis; tazobactam inhibits beta-lactamases

Drug Class

Antibiotic

Subclass

Ureidopenicillin + Beta-lactamase inhibitor

Zosyn

Half-life

0.7-1.2 hours

Time for plasma concentration to decrease by 50%

Protein Binding

30%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses