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Pioglitazone

Oseni, Actos, Actoplus Met, Duetact

Uncategorized

Standard

Half-life

3-7 hours (active metabolites: 16-24 hours)

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

May cause or exacerbate heart failure

Clinical alerts

Boxed warning

1 boxed warning

Hepatotoxic

Monitor liver function

Mechanism of action

Activates PPARgamma receptor, improving insulin sensitivity in muscle and adipose tissue

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Cocaine Use Disorder
·Multiple Sclerosis
·Type1diabetes
·Healthy Participants
·Advanced Solid Tumor

Interactions

No curated interaction pairs are recorded for Pioglitazone. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Weight gain
Edema
Fractures
Upper respiratory infections

Food, alcohol & herbal

Alcohol · moderate

May increase hypoglycemia risk

Pharmacokinetics

Half-life: 3-7 hours (active metabolites: 16-24 hours)
Protein binding: 99%
Metabolised by: CYP2C8, CYP3A4
Induces: CYP3A4

Pregnancy & lactation

Not recorded for Pioglitazone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Pioglitazone

Oseni, Actos, Actoplus Met, Duetact

Uncategorized

Standard

Half-life

3-7 hours (active metabolites: 16-24 hours)

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

May cause or exacerbate heart failure

Clinical alerts

Boxed warning

1 boxed warning

Hepatotoxic

Monitor liver function

Mechanism of action

Activates PPARgamma receptor, improving insulin sensitivity in muscle and adipose tissue

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Cocaine Use Disorder
·Multiple Sclerosis
·Type1diabetes
·Healthy Participants
·Advanced Solid Tumor

Interactions

No curated interaction pairs are recorded for Pioglitazone. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Weight gain
Edema
Fractures
Upper respiratory infections

Food, alcohol & herbal

Alcohol · moderate

May increase hypoglycemia risk

Pharmacokinetics

Half-life: 3-7 hours (active metabolites: 16-24 hours)
Protein binding: 99%
Metabolised by: CYP2C8, CYP3A4
Induces: CYP3A4

Pregnancy & lactation

Not recorded for Pioglitazone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement